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ARECOLIN HYDROBROMIDE VETRANAL, 250

Arecoline hydrobromide

CAS: 300-08-3

Molecular Formula: C8H14BrNO2

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ARECOLIN HYDROBROMIDE VETRANAL, 250 - Names and Identifiers

Name Arecoline hydrobromide
Synonyms arecane
Arecoline HBr
arecolinebromide
arekolinhydrobromid
Arecoline hydrobromide
ARECOLINE HYDROBROMIDE CRYSTALLINE
ARECOLIN HYDROBROMIDE VETRANAL, 250
ARECOLINE HYDROBROMIDE CHOLINERGIC AGONI ST
methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide
1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
CAS 300-08-3
EINECS 206-087-3
InChI InChI=1/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChIKey AXOJRQLKMVSHHZ-UHFFFAOYSA-N

ARECOLIN HYDROBROMIDE VETRANAL, 250 - Physico-chemical Properties

Molecular FormulaC8H14BrNO2
Molar Mass236.11
Melting Point171-175°C
Boling Point209°C at 760 mmHg
Flash Point81.1°C
Solubility H2O: 0.1g/mL, clear, colorless
Vapor Presure0.208mmHg at 25°C
AppearancePowder
ColorWhite to light yellow
Merck14,778
BRN3914826
pKa6.84(at 25℃)
Storage ConditionInert atmosphere,Room Temperature
StabilityStable for 2 years from date of purchase as supplied. Solutions are not stable – make fresh daily.
Physical and Chemical PropertiesThis product is white or light yellow crystalline powder; Odorless, bitter taste. It is soluble in water and ethanol, slightly soluble in chloroform and ether, and the aqueous solution is relatively stable. It should be stored in a container protected from light.

ARECOLIN HYDROBROMIDE VETRANAL, 250 - Risk and Safety

Risk CodesR22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety DescriptionS45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S38 - In case of insufficient ventilation, wear suitable respiratory equipment.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S28A -
UN IDs1544
WGK Germany3
RTECSQT2275000
FLUKA BRAND F CODES8
HS Code29399990
Hazard Class6.1
Packing GroupIII
ToxicityLD50 par-rat: 270 mg/kg ABMGAJ 28,681,72

ARECOLIN HYDROBROMIDE VETRANAL, 250 - Reference Information

EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Overview Arecoline is an alkaloid in the seeds of the plant areca nut, and its hydrobromide is commonly used clinically [1]. White crystalline powder, odorless, bitter, poisonous, deteriorated in case of light. Melting point 170- 171 ℃. Soluble in water and ethanol. It is obtained by the reaction of arecoline with hydrobromic acid ethanol solution. Intestinal insect repellent drugs are mostly used for veterinary treatment [2].

figure 1 arecoline hydrobromide tablets
research on antithrombotic effect research on antithrombotic and thrombolytic effects of arecoline hydrobromide on thrombus in vivo and in vitro. Methods: The thrombolytic effect of arecoline hydrobromide in vitro was investigated by the dissolution of human blood clots and human platelet plasma clots in vitro.

The anti-thrombotic effect of arecoline hydrobromide in vivo was investigated by the model of carrageenan-induced tail vein thrombosis in mice. Results: Arecoline hydrobromide can accelerate the dissolution of human blood clots and platelet plasma clots in vitro, and has a dose-dependent effect of

; it has the effect of anti-carrageenan-induced tail vein thrombosis in mice. Conclusion: Hydrobromic acid

arecoline has antithrombotic effect in vivo and in vitro.
pharmacological action arecoline hydrobromide has a strong paralyzing effect on tapeworm muscles, causing the worm body to lose the ability to cling to the intestinal wall. in addition, the muscarinic effect of the drug on the host strengthens intestinal peristalsis and increases secretion of digestive glands, which is conducive to the rapid elimination of paralytic worms.
This product is effective for all tapeworms in dogs. It can also repel taenia, polycephalus and Echinococcus granulosus. It also has an repellent effect on avian tapeworms.
clinical application is mainly used for taeniasis common in dogs and poultry.
usage and dosage oral administration: one dose, per kilogram of body weight, 1.5-2 mg for dogs, 3 mg for chickens, 1-2 mg for ducks and geese.
adverse reactions and poisoning rescue (1) the use of normal dose of arecoline hydrobromide has less adverse reactions to dogs, and vomiting, diarrhea, secondary coma and convulsion can obviously occur when overdose. The general poisoning dose can be as much as 8 times the therapeutic dose.
(2) This product is not safe for cats, and it can make their bronchi secrete a large amount of mucus and cause cats to suffocate and die.
(3) atropine can detoxify and relieve symptoms of this product.
precautions (1) dogs should fast for 12 hours before medication. if they still do not defecate 2 hours after medication, they should be taken with saline to accelerate the elimination of paralysis.
(2) chickens have strong tolerance to this product, followed by ducks and geese, equine animals are more sensitive, and cats are the most sensitive, so it is advisable not to use it.
(3) Due to the high toxicity of this product, it has been banned in the United States.
drug combination atropine: it can detoxify arecoline and relieve symptoms, and can be used to rescue arecoline poisoning.
Choline-like drugs such as pilocarpine: the combination of the two can enhance the toxicity.
Pumpkin seeds: The combination of arecoline and pumpkin seeds can repel naked head tapeworm.
References [1] Wang Kunhua, edited by Yang Zhikang. Guidelines for rational clinical application of veterinary drugs. Kunming: Yunnan Science and Technology Press. 2010.
[2] Ma Shichang editor-in-chief. Dictionary of organic compounds. Xi'an: Shaanxi Science and Technology Press. 1988. Page 284.
[3] Tang Fei, Wang Hao, Liu Weijun. Study on antithrombotic effect of arecoline hydrobromide [J]. Chinese Journal of Hospital Pharmacy, 2009,29(10):791-793.
use for content determination/identification/pharmacological experiments, etc.
category toxic substances
toxicity classification highly toxic
acute toxicity subcutaneous-mouse LDL0: 65 mg/kg; Intravenous-mouse LD50: 18 mg/kg
flammability hazard characteristics combustible; combustion produces toxic nitrogen oxides and hydrogen bromide smoke
storage and transportation characteristics warehouse ventilation and low temperature drying; separate from food raw materials
fire extinguishing agent dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-09 15:16:44
ARECOLIN HYDROBROMIDE VETRANAL, 250
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Product Name: Tranexamic Acid Impurity 41 Visit Supplier Webpage Request for quotation
CAS: 300-08-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Arecoline hydrobromide Request for quotation
CAS: 300-08-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Arecoline hydrobromide Visit Supplier Webpage Request for quotation
CAS: 300-08-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Arecoline hydrobromide Request for quotation
CAS: 300-08-3
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
systempharm（HN) Co.,Ltd.
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CAS: 300-08-3
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Email:
Mobile: 18699207379
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ARECOLIN HYDROBROMIDE VETRANAL, 250
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